In the June 29th edition of biobytes, Matthew Tyska (Vanderbilt University, Nashville, TN) reveals how the intestinal brush border sends out packages of enzymes to combat gut pathogens (McConnell et al., JCB); Alwin Kraemer (German Cancer Research Center, Heidelberg) explains how two centrosomal proteins mutated in neurodevelopmental disorders regulate mitotic entry (Tibelius et al., JCB); and JEM news editor Amy Maxmen describes how an immune pathway helps tumors grow (Wang et al., JEM). The show was written and produced by Amy Maxmen, Ben Short and Ruth Williams. Presented by Ruth Williams.